ARG43974
anti-PRPF19 antibody
anti-PRPF19 antibody for ELISA,Flow cytometry,ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PRPF19 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PRPF19 |
| Antigen Species | Human |
| Immunogen | Human PRPF19 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | Pre-mRNA-processing factor 19 |
| Alternate Names | PRPF19; Pre-MRNA Processing Factor 19; NMP200; SNEV; UBOX4; HPSO4; PRP19; PSO4; Nuclear Matrix Protein NMP200 Related To Splicing Factor PRP19; RING-Type E3 Ubiquitin Transferase PRP19; Pre-MRNA-Processing Factor 19; Nuclear Matrix Protein 200; Senescence Evasion Factor; PRP19/PSO4 Homolog; Psoralen 4; PRP19/PSO4 Pre-MRNA Processing Factor 19 Homolog (S. Cerevisiae) ; PRP19/PSO4 Homolog (S. Cerevisiae); EC 2.3.2.27; HPso4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified with Immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PRPF19 |
| Gene Full Name | Pre-MRNA Processing Factor 1 |
| Background | Enables identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in several processes, including DNA damage checkpoint signaling; cellular protein metabolic process; and mRNA splicing, via spliceosome. Acts upstream of or within protein polyubiquitination. Located in cytoplasm; nuclear speck; and site of double-strand break. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. |
| Function | Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. |
| Cellular Localization | Cytoplasm, Cytoskeleton, Lipid droplet, Nucleus, Spliceosome |
| Calculated MW | 55 kDa |
| PTM | Acetylation |
