ARG43978
anti-PRPF8 antibody
anti-PRPF8 antibody for ELISA,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PRPF8 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ELISA, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PRPF8 |
| Antigen Species | Human |
| Immunogen | Human PRPF8 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | Pre-mRNA-processing-splicing factor 8 |
| Alternate Names | PRPF8; Pre-MRNA Processing Factor 8; PRPC8; SNRNP220; Pre-MRNA-Processing-Splicing Factor 8; 220 KDa U5 SnRNP-Specific Protein; Splicing Factor Prp8; PRP8 Homolog; HPrp8; Prp8; RP13; P220; U5 SnRNP-Specific Protein (220 KD), Ortholog Of S. Cerevisiae Prp8p; PRP8 Pre-MRNA Processing Factor 8 Homolog; Precursor MRNA Processing Protein; Apoptosis-Regulated Protein; HPRP8; PRP8 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified with Immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6P2Q9 Human Pre-mRNA-processing-splicing factor 8 Swiss-port # Q99PV0 Mouse Pre-mRNA-processing-splicing factor 8 |
|---|---|
| Gene Symbol | PRPF8 |
| Gene Full Name | Pre-MRNA Processing Factor 8 |
| Background | Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. |
| Function | Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. |
| Cellular Localization | Nucleus, Spliceosome |
| Calculated MW | 274 kDa |
| PTM | Acetylation, Methylation, Phosphoprotein |
