ARG43996
anti-PSMD14 antibody
anti-PSMD14 antibody for ELISA,Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PSMD14 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ELISA, FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PSMD14 |
| Antigen Species | Human |
| Immunogen | Human PSMD14 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | 26S proteasome non-ATPase regulatory subunit 14 |
| Alternate Names | PSMD14; Proteasome 26S Subunit, Non-ATPase 14; POH1; Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14; 26S Proteasome Non-ATPase Regulatory Subunit 14; 26S Proteasome-Associated PAD1 Homolog 1; Rpn11; Pad1; Testis Tissue Sperm-Binding Protein Li 69n; 26S Proteasome Regulatory Subunit Rpn11; 26S Proteasome Regulatory Subunit RPN11; EC 3.4.19.- ; EC 3.1.2.15; RPN11; PAD1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified with Immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O00487 Human 26S proteasome non-ATPase regulatory subunit 14 Swiss-port # O35593 Mouse 26S proteasome non-ATPase regulatory subunit 14 |
|---|---|
| Gene Symbol | PSMD14 |
| Gene Full Name | Proteasome 26S Subunit, Non-ATPase 14 |
| Background | This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. |
| Cellular Localization | Proteasome |
| Calculated MW | 35 kDa |
| PTM | Phosphoprotein |
