ARG55473
anti-PSMD2 / Proteasome 26S S2 antibody
anti-PSMD2 / Proteasome 26S S2 antibody for ICC/IF,Western blot and Human,Mouse
Cell Biology and Cellular Response antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PSMD2 / Proteasome 26S S2 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PSMD2 / Proteasome 26S S2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human PSMD2 |
| Conjugation | Un-conjugated |
| Alternate Names | RPN1; TRAP2; 26S proteasome subunit p97; S2; Protein 55.11; P97; 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit S2; 26S proteasome regulatory subunit RPN1; Tumor necrosis factor type 1 receptor-associated protein 2 |
Application Instructions
| Predict Reactivity Note | Rat | ||||||
|---|---|---|---|---|---|---|---|
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | SW480 and Mouse liver | ||||||
| Observed Size | ~ 100 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q13200 Human 26S proteasome non-ATPase regulatory subunit 2 Swiss-port # Q8VDM4 Mouse 26S proteasome non-ATPase regulatory subunit 2 |
|---|---|
| Gene Symbol | PSMD2 |
| Gene Full Name | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 |
| Background | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| Function | Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. [UniProt] |
| Research Area | Cell Biology and Cellular Response antibody |
| Calculated MW | 100 kDa |
