ARG40547
anti-PTPN13 / FAP1 antibody
anti-PTPN13 / FAP1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes PTPN13 / FAP1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | PTPN13 / FAP1 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 250-500 of Human PTPN13 / FAP1 (NP_542416.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Protein-tyrosine phosphatase 1E; hPTP1E; PTPLE; hPTPE1; PNP1; Tyrosine-protein phosphatase non-receptor type 13; PTP1E; PTP-BL; PTP-E1; FAP-1; Protein-tyrosine phosphatase PTPL1; Fas-associated protein-tyrosine phosphatase 1; PTP-BAS; PTPL1; EC 3.1.3.48 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | A549 | ||||||
| Observed Size | 310 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q12923 Human Tyrosine-protein phosphatase non-receptor type 13 Swiss-port # Q64512 Mouse Tyrosine-protein phosphatase non-receptor type 13 |
|---|---|
| Gene Symbol | PTPN13 |
| Gene Full Name | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) |
| Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008] |
| Function | Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2. [UniProt] |
| Cellular Localization | Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. Note=Colocalizes with F-actin. Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover. [UniProt] |
| Calculated MW | 277 kDa |
