ARG22694
anti-Pepsinogen I antibody [8003 (99/12)]
anti-Pepsinogen I antibody [8003 (99/12)] for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Radioimmunoassay and Human
Overview
| Product Description | Mouse Monoclonal antibody [8003 (99/12)] recognizes Pepsinogen I This antibody recognizes Human Pepsinogen I, a zymogen or proenzyme secreted by chief cells in the stomach. It is cleaved to form pepsin both in an autocatalytic fashion and by pepsin itself. In Humans there are two related forms of pepsin, Pepsinogen I (also known as pepsinogen A), and Pepsinogen II (also known as Pepsinogen B or progastricsin). |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, IHC-P, RIA |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 8003 (99/12) |
| Isotype | IgG1 |
| Target Name | Pepsinogen I |
| Antigen Species | Human |
| Immunogen | Purified human Pepsinogen I. |
| Conjugation | Un-conjugated |
| Alternate Names | EC 3.4.23.1; Pepsinogen-3; Pepsin A-3 |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Boil tissue section in Sodium citrate buffer (pH 6.0) * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PGA3 |
| Gene Full Name | pepsinogen 3, group I (pepsinogen A) |
| Background | This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015] |
| Function | Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. [UniProt] |
| Calculated MW | 42 kDa |
