ARG59480
anti-Peroxiredoxin 3 antibody
anti-Peroxiredoxin 3 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Immunoprecipitation,Flow cytometry and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Peroxiredoxin 3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, IHC-P, IP, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Peroxiredoxin 3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of Human Peroxiredoxin 3. |
| Conjugation | Un-conjugated |
| Alternate Names | EC 1.11.1.15; Antioxidant protein 1; Prx-III; SP-22; AOP1; AOP-1; MER5; HBC189; PRO1748; Peroxiredoxin-3; Thioredoxin-dependent peroxide reductase, mitochondrial; prx-III; Peroxiredoxin III; Protein MER5 homolog |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P30048 Human Thioredoxin-dependent peroxide reductase, mitochondrial |
|---|---|
| Gene Symbol | PRDX3 |
| Gene Full Name | peroxiredoxin 3 |
| Background | This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014] |
| Function | Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. [UniProt] |
| Cellular Localization | Mitochondrion. Cytoplasm. Early endosome. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. [UniProt] |
| Calculated MW | 28 kDa |
| PTM | Phosphorylated by LRRK2; phosphorylation reduces perodixase activity. [UniProt] |
