ARG58162
anti-Phospholipase C beta 1 antibody
anti-Phospholipase C beta 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Phospholipase C beta 1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Phospholipase C beta 1 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 917-1216 of Human Phospholipase C beta 1 (NP_056007.1). |
| Conjugation | Un-conjugated |
| Alternate Names | EC 3.1.4.11; EIEE12; PLCB1B; PLC154; PLCB1A; Phospholipase C-I; PLC-I; Phosphoinositide phospholipase C-beta-1; Phospholipase C-beta-1; PLC-154; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PI-PLC; PLC-beta-1 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | NCI-H460 | ||||||
| Observed Size | 145 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PLCB1 |
| Gene Full Name | phospholipase C, beta 1 (phosphoinositide-specific) |
| Background | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. [UniProt] |
| Cellular Localization | Nucleus membrane, Cytoplasm. [UniProt] |
| Calculated MW | 139 kDa |
