ARG10258
anti-Proinsulin antibody [1D6]
anti-Proinsulin antibody [1D6] for ELISA and Human
Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
Overview
Product Description | Mouse Monoclonal antibody [1D6] recognizes Proinsulin |
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Tested Reactivity | Hu |
Tested Application | ELISA |
Specificity | Do not cross-react with human, bovine and porcine insulin, bovine and porcine proinsulin, and human C-peptide. |
Host | Mouse |
Clonality | Monoclonal |
Clone | 1D6 |
Isotype | IgG1 |
Target Name | Proinsulin |
Antigen Species | Human |
Immunogen | purified human proinsulin |
Conjugation | Un-conjugated |
Alternate Names | IDDM; IDDM2; IDDM1; ILPR; MODY10; Insulin; IRDN |
Application Instructions
Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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Properties
Form | Liquid |
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Purification | Protein A affinity purified. |
Buffer | PBS (pH 7.4) and 0.1% Sodium azide |
Preservative | 0.1% Sodium azide |
Concentration | 1.0-2.0 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | INS |
Gene Full Name | insulin |
Background | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] |
Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. [UniProt] |
Research Area | Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
Calculated MW | 12 kDa |