ARG43053
anti-RAB3GAP2 antibody
anti-RAB3GAP2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Flow cytometry,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RAB3GAP2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RAB3GAP2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to M1-Q115 of Human RAB3GAP2. |
| Conjugation | Un-conjugated |
| Alternate Names | Rab3-GAP p150; p150; RGAP-iso; RAB3-GAP150; Rab3-GAP regulatory subunit; RAB3GAP150; Rab3-GAP150; Rab3 GTPase-activating protein non-catalytic subunit; SPG69; WARBM2; Rab3 GTPase-activating protein 150 kDa subunit |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Heat mediation was performed in Citrate buffer (pH 6.0) for 20 min. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RAB3GAP2 |
| Gene Full Name | RAB3 GTPase activating protein subunit 2 (non-catalytic) |
| Background | The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome. [provided by RefSeq, Oct 2009] |
| Function | Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. [UniProt] |
| Cellular Localization | Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction. [UniProt] |
| Calculated MW | 156 kDa |
