ARG23609
anti-RANK antibody [LOB14-8]
anti-RANK antibody [LOB14-8] for ELISA,Flow cytometry,Immunoprecipitation and Mouse
Overview
| Product Description | Rat Monoclonal antibody [LOB14-8] recognizes RANK. This product recognizes murine receptor activator of NF Kappa-B (RANK), otherwise known as CD265. CD265 is a member of the tumour necrosis factor (TNF) receptor superfamily and plays an important role in lymph node development and osteoclast differentiation. |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | ELISA, FACS, IP |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | LOB14-8 |
| Isotype | IgG2a |
| Target Name | RANK |
| Antigen Species | Mouse |
| Immunogen | RANK-Fc fusion protein. |
| Conjugation | Un-conjugated |
| Alternate Names | ODFR; Osteoclast differentiation factor receptor; OFE; FEO; CD265; PDB2; CD antigen CD265; RANK; Receptor activator of NF-KB; OPTB7; Tumor necrosis factor receptor superfamily member 11A; TRANCER; LOH18CR1; OSTS |
Application Instructions
| Application Suggestion |
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| Application Note | FACS: Use 20 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O35305 Mouse Tumor necrosis factor receptor superfamily member 11A |
|---|---|
| Gene Symbol | TNFRSF11A |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012] |
| Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. [UniProt] |
| Calculated MW | 66 kDa |
