ARG41302
anti-RBBP6 antibody
anti-RBBP6 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RBBP6 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RBBP6 |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to aa. 97-351 of Human RBBP6. |
| Conjugation | Un-conjugated |
| Alternate Names | PACT; Retinoblastoma-binding protein 6; E3 ubiquitin-protein ligase RBBP6; EC 6.3.2.-; SNAMA; Proliferation potential-related protein; RBQ-1; Protein P2P-R; Retinoblastoma-binding Q protein 1; MY038; P2P-R; p53-associated cellular protein of testis |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Mouse brain |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | 0.01M PBS (pH 7.4), 0.03% Proclin 300 and 50% Glycerol. |
| Preservative | 0.03% Proclin 300 |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RBBP6 |
| Gene Full Name | retinoblastoma binding protein 6 |
| Background | The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. [UniProt] |
| Cellular Localization | Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome. [UniProt] |
| Calculated MW | 202 kDa |
| PTM | Phosphorylated by NEK6. [UniProt] |
