ARG58743
anti-RECK antibody
anti-RECK antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RECK |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RECK |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 110-210 of Human RECK (NP_066934.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Reversion-inducing cysteine-rich protein with Kazal motifs; hRECK; ST15; Suppressor of tumorigenicity 15 protein |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | 293T | ||||
| Observed Size | 110 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O95980 Human Reversion-inducing cysteine-rich protein with Kazal motifs Swiss-port # Q9Z0J1 Mouse Reversion-inducing cysteine-rich protein with Kazal motifs |
|---|---|
| Gene Symbol | RECK |
| Gene Full Name | reversion-inducing-cysteine-rich protein with kazal motifs |
| Background | The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. [provided by RefSeq, Jul 2008] |
| Function | Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. [UniProt] |
| Cellular Localization | Cell membrane, Lipid-anchor, GPI-anchor. [UniProt] |
| Calculated MW | 106 kDa |
| PTM | N-glycosylated. [UniProt] |
