ARG41281

anti-RGS7 antibody

anti-RGS7 antibody for Western blot and Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes RGS7
Tested Reactivity Ms
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name RGS7
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 1-300 of Human RGS7 (NP_002915.3).
Conjugation Un-conjugated
Alternate Names RGS7; Regulator of G-protein signaling 7

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse brain
Observed Size 58 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 24012 Mouse RGS7

Swiss-port # O54829 Mouse Regulator of G-protein signaling 7

Gene Symbol RGS7
Gene Full Name regulator of G-protein signaling 7
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity). [UniProt]
Cellular Localization Cytoplasm, cytosol. Cytoplasm. Cell membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264). [UniProt]
Calculated MW 58 kDa
PTM Palmitoylated.

Ubiquitinated, leading to rapid proteasomal degradation.

Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. [UniProt]