ARG40066
anti-RNASEH2C / RNase H2 subunit C antibody
anti-RNASEH2C / RNase H2 subunit C antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RNASEH2C / RNase H2 subunit C |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RNASEH2C / RNase H2 subunit C |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-164 of Human RNASEH2C (NP_115569.2). |
| Conjugation | Un-conjugated |
| Alternate Names | RNase H1 small subunit; Ribonuclease H2 subunit C; Aicardi-Goutieres syndrome 3 protein; AGS3; RNase H2 subunit C; AYP1; Ribonuclease HI subunit C |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | 293T | ||||
| Observed Size | 18 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RNASEH2C |
| Gene Full Name | ribonuclease H2, subunit C |
| Background | This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008] |
| Function | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 18 kDa |
