ARG64109

anti-RNF213 / C17orf 27 antibody

anti-RNF213 / C17orf 27 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human

Cell Biology and Cellular Response antibody

Overview

Product Description Goat Polyclonal antibody recognizes RNF213 / C17orf 27
Tested Reactivity Hu
Tested Application IHC-P
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name RNF213 / C17orf 27
Antigen Species Human
Immunogen C-KTAAVLKWNRE
Conjugation Un-conjugated
Alternate Names MYMY2; EC 6.3.2.-; NET57; E3 ubiquitin-protein ligase RNF213; ALK lymphoma oligomerization partner on chromosome 17; KIAA1618; RING finger protein 213; Mysterin; ALO17; MYSTR; C17orf27

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P2.5 µg/ml
Application Note IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 57674 Human RNF213

Swiss-port # Q63HN8 Human E3 ubiquitin-protein ligase RNF213

Background This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Research Area Cell Biology and Cellular Response antibody
Calculated MW 591 kDa
PTM Autoubiquitinated.