ARG43820
anti-RUNX1 + RUNX2 + RUNX3 antibody
anti-RUNX1 + RUNX2 + RUNX3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes RUNX1 + RUNX2 + RUNX3 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Specificity | Human,Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | RUNX1 + RUNX2 + RUNX3 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide of human RUNX1/2/3. |
| Conjugation | Un-conjugated |
| Protein Full Name | Runt-related transcription factor 1/2/3 |
| Alternate Names | RUNX1; RUNX Family Transcription Factor 1; Runt-Related Transcription Factor 1; AMLCR1; CBFA2; AML1; Polyomavirus Enhancer-Binding Protein 2 Alpha B Subunit; SL3/AKV Core-Binding Factor Alpha B Subunit; SL3-3 Enhancer Factor 1 Alpha B Subunit; Runt Related Transcription Factor 1; Acute Myeloid Leukemia 1 Protein; Oncogene AML-1; PEBP2-Alpha B; PEA2-Alpha B; PEBP2A2; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Core-Binding Factor Subunit Alpha-2; AML1-EVI-1 Fusion Protein; Acute Myeloid Leukemia 1; AML1-ETO Fusion Protein; AML1-ETO Fusion; Aml1 Oncogene; Mutant RUNX1; CBF-Alpha-2; AML1-EVI-1; PEBP2alpha; CBF2alpha; PEBP2aB; EVI-1; RUNX2; RUNX Family Transcription Factor 2; AML3; Runt-Related Transcription Factor 2; CBFA1; Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit; SL3/AKV Core-Binding Factor Alpha A Subunit; Osteoblast-Specific Transcription Factor 2; SL3-3 Enhancer Factor 1 Alpha A Subunit; Runt Related Transcription Factor 2; Acute Myeloid Leukemia 3 Protein; Oncogene AML-3; PEBP2-Alpha A; PEA2-Alpha A; CBF-Alpha-1; PEBP2aA1; PEBP2A1; OSF-2; CCD1; OSF2; CCD; Core-Binding Factor, Runt Domain, Alpha Subunit 1; Core-Binding Factor Subunit Alpha-1; PEBP2aA; PEA2aA; PEBP2A; CLCD; RUNX3; RUNX Family Transcription Factor 3; AML2; Runt-Related Transcription Factor 3; PEBP2A3; CBFA3; Polyomavirus Enhancer-Binding Protein 2 Alpha C Subunit; SL3/AKV Core-Binding Factor Alpha C Subunit; SL3-3 Enhancer Factor 1 Alpha C Subunit; Runt Related Transcription Factor 3; Core-Binding Factor Subunit Alpha-3; Acute Myeloid Leukemia 2 Protein; Oncogene AML-2; CBF-Alpha-3; Core-Binding Factor, Runt Domain, Alpha Subunit 3; Acute Myeloid Leukemia Gene 2; Transcription Factor AML2; PEBP2 Alpha C; PEBP2-Alpha C; PEA2 Alpha C; PEA2-Alpha C; PEBP2aC |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 49 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | Tris-Glycine, 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q01196 Human Runt-related transcription factor 1 |
|---|---|
| Gene Symbol | RUNX1/RUNX2/RUNX3 |
| Gene Full Name | RUNX Family Transcription Factor 1/2/3 |
| Background | Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis. [UniProt] |
| Cellular Localization | Cytoplasm, Nucleus. [UniProt] |
| Calculated MW | 49 kDa |
| PTM | Acetylation, Methylation, Phosphoprotein, Isopeptide bond, Ubl conjugation. [UniProt] |
