ARG56988
anti-Ribonuclease Inhibitor antibody [1H23]
anti-Ribonuclease Inhibitor antibody [1H23] for ICC/IF,Western blot and Human,Mouse
Overview
| Product Description | Mouse Monoclonal antibody [1H23] recognizes Ribonuclease Inhibitor |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ICC/IF, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1H23 |
| Isotype | IgG2a, kappa |
| Target Name | Ribonuclease Inhibitor |
| Antigen Species | Human |
| Immunogen | Recombinant fragment around aa. 7-461 of Human Ribonuclease Inhibitor. |
| Conjugation | Un-conjugated |
| Alternate Names | RNH; Ribonuclease/angiogenin inhibitor 1; RAI; Ribonuclease inhibitor; Placental ribonuclease inhibitor; Placental RNase inhibitor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 10% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | RNH1 |
| Gene Full Name | ribonuclease/angiogenin inhibitor 1 |
| Background | Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010] |
| Function | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. [UniProt] |
| Calculated MW | 50 kDa |
| PTM | The N-terminus is blocked. At least 30 of the 32 cysteine residues are in the reduced form. |
