ARG58970
anti-SAMHD1 antibody
anti-SAMHD1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
Product Description | Rabbit Polyclonal antibody recognizes SAMHD1 |
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Tested Reactivity | Hu, Ms, Rat |
Tested Application | IHC-P, IP, WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | SAMHD1 |
Antigen Species | Human |
Immunogen | Recombinant fusion protein corresponding to aa. 387-626 of Human SAMHD1 (NP_056289.2). |
Conjugation | Un-conjugated |
Alternate Names | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; EC 3.1.5.-; SBBI88; SAM domain and HD domain-containing protein 1; HDDC1; MOP-5; DCIP; CHBL2; dNTPase; Dendritic cell-derived IFNG-induced protein; Monocyte protein 5 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
Positive Control | HepG2 | ||||||||
Observed Size | 72 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # Q60710 Mouse Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Swiss-port # Q9Y3Z3 Human Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
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Gene Symbol | SAMHD1 |
Gene Full Name | SAM domain and HD domain 1 |
Background | This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010] |
Function | Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. [UniProt] |
Cellular Localization | Nucleus. [UniProt] |
Calculated MW | 72 kDa |
PTM | Ubiquitinated and targeted for proteasomal degradation by a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase with the help of the viral accessory protein Vpx. [UniProt] |