ARG44284
anti-SARM1 antibody
anti-SARM1 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SARM1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SARM1 |
| Antigen Species | Human |
| Immunogen | Full length recombinant human SARM1 protein |
| Conjugation | Un-conjugated |
| Alternate Names | SARM1; Sterile Alpha And TIR Motif Containing 1; SAMD2; SARM; KIAA0524; Sterile Alpha And TIR Motif-Containing Protein 1; Sterile Alpha Motif Domain-Containing Protein 2; Sterile Alpha And Armadillo Repeat Protein; SAM Domain-Containing Protein 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 50% Glycerol and 100 µg/ml BSA. |
| Stabilizer | 50% Glycerol and 100 µg/ml BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q6PDS3 Mouse Sterile alpha and TIR motif-containing protein 1 Swiss-port # Q6SZW1 Human Sterile alpha and TIR motif-containing protein 1 |
|---|---|
| Gene Symbol | SARM1 |
| Gene Full Name | Sterile Alpha And TIR Motif Containing 1 |
| Background | Enables NAD+ nucleotidase, cyclic ADP-ribose generating and identical protein binding activity. Involved in NAD catabolic process; positive regulation of neuron death; and response to axon injury. Located in mitochondrion. |
| Function | Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. |
| Cellular Localization | Cell projection, Cytoplasm, Mitochondrion, Synapse |
| Calculated MW | 79 kDa |
| PTM | Phosphoprotein |
