ARG63645
anti-SART1 antibody
anti-SART1 antibody for Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes SART1 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, Cow |
| Tested Application | WB |
| Specificity | This antibody is expected to recognise both the human SART1(800) and SART1(259) proteins. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SART1 |
| Antigen Species | Human |
| Immunogen | GSSKKHRGEKEAA-C |
| Conjugation | Un-conjugated |
| Alternate Names | allergen Hom s 1; Snu66; Ara1; hSnu66; U4/U6.U5 tri-snRNP-associated 110 kDa protein; U4/U6.U5 tri-snRNP-associated protein 1; SNU66 homolog; Squamous cell carcinoma antigen recognized by T-cells 1; HOMS1; hSART-1; SART1259; SNRNP110; SART-1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by antigen affinity chromatography. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O43290 Human U4/U6.U5 tri-snRNP-associated protein 1 |
|---|---|
| Background | This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008] |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody |
| Calculated MW | 90 kDa |
| PTM | Sumoylated with SUMO2. |
