ARG57995
anti-SCARB1 / SRB1 antibody
anti-SCARB1 / SRB1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SCARB1 / SRB1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SCARB1 / SRB1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human SCARB1 / SR-BI. |
| Conjugation | Un-conjugated |
| Alternate Names | CLA-1; HDLQTL6; CD36L1; CD antigen CD36; CD36 antigen-like 1; CD36 and LIMPII analogous 1; Collagen type I receptor, thrombospondin receptor-like 1; Scavenger receptor class B member 1; SRB1; SR-BI; CLA1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Human fetal liver | ||||||
| Observed Size | ~ 76 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q61009 Mouse Scavenger receptor class B member 1 Swiss-port # Q8WTV0 Human Scavenger receptor class B member 1 |
|---|---|
| Gene Symbol | SCARB1 |
| Gene Full Name | scavenger receptor class B, member 1 |
| Background | The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity). [UniProt] |
| Calculated MW | 61 kDa |
| PTM | N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. [UniProt] |
