ARG43562

anti-SCARB2 / LIMP2 antibody

anti-SCARB2 / LIMP2 antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Flow cytometry and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes SCARB2 / LIMP2.
Tested Reactivity Hu, Ms, Rat
Tested Application FACS, IHC-P, IP, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name SCARB2 / LIMP2
Antigen Species Human
Immunogen Synthetic peptide derived from human SCARB2 / LIMP2
Protein Full Name Lysosome membrane protein 2
Alternate Names AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:20 - 1:200
IHC-P1:50 - 1:200
IP1:10 - 1:50
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 117106 Rat SCARB2

GeneID: 12492 Mouse SCARB2

GeneID: 950 Human SCARB2

Gene Symbol SCARB2
Gene Full Name scavenger receptor class B, member 2
Background The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Function Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. [UniProt]