ARG42952

anti-SDHC antibody

anti-SDHC antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes SDHC
Tested Reactivity Hu, Ms, Rat
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name SDHC
Antigen Species Human
Immunogen Synthetic peptide corresponding to aa. 35-50 of Human SDHC. (KEEMERFWNKNIGSNR)
Conjugation Un-conjugated
Alternate Names Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; QPs1; Integral membrane protein CII-3; SDH3; CYB560; PGL3; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; QPS1; QPs-1; CYBL

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P1:200 - 1:1000
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size ~ 19 kDa

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA.
Preservative 0.05% Thimerosal and 0.05% Sodium azide
Stabilizer 5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 6391 Human SDHC

GeneID: 66052 Mouse SDHC

Swiss-port # Q99643 Human Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Swiss-port # Q9CZB0 Mouse Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Gene Symbol SDHC
Gene Full Name succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
Background This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]
Function Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). [UniProt]
Cellular Localization Mitochondrion inner membrane; Multi-pass membrane protein. [UniProt]
Calculated MW 19 kDa