ARG44349
anti-SEC14L2 / TAP antibody
anti-SEC14L2 / TAP antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SEC14L2 / TAP |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SEC14L2 / TAP |
| Antigen Species | Human |
| Immunogen | Human SEC14L2 / TAP recombinant fusion protein (a.a. sequence: 60-270). |
| Conjugation | Un-conjugated |
| Alternate Names | SEC14L2; SEC14 Like Lipid Binding 2; TAP; SPF; Supernatant Protein Factor; KIAA1186; KIAA1658; C22orf6; TAP1; Alpha-Tocopherol-Associated Protein; Tocopherol-Associated Protein 1; Squalene Transfer Protein; SEC14-Like Protein 2; SEC14 (S. Cerevisiae)-Like 2; SEC14-Like 2 (S. Cerevisiae); SEC14-Like Lipid Binding 2; HTAP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS, 0.01% Thimerosal and 50% Glycerol. |
| Preservative | 0.01% Thimerosal |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SEC14L2 |
| Gene Full Name | SEC14 Like Lipid Binding 2 |
| Background | This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
| Function | Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. |
| Cellular Localization | Cytoplasm, Nucleus |
| Calculated MW | 46 kDa |
