ARG58658

anti-SERPINB1 antibody

anti-SERPINB1 antibody for Western blot,ICC/IF and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes SERPINB1
Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name SERPINB1
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 100-379 of Human SERPINB1 (NP_109591.1).
Conjugation Un-conjugated
Alternate Names EI; LEI; ELANH2; Monocyte/neutrophil elastase inhibitor; Leukocyte elastase inhibitor; M/NEI; Serpin B1; MNEI; PI-2; PI2; Peptidase inhibitor 2; HEL57

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IF1:20 - 1:100
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control MCF7
Observed Size 43 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1992 Human SERPINB1

Swiss-port # P30740 Human Leukocyte elastase inhibitor

Gene Symbol SERPINB1
Gene Full Name serpin peptidase inhibitor, clade B (ovalbumin), member 1
Background The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Function Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H. [UniProt]
Cellular Localization Cytoplasm, Cytoplasmic granule. [UniProt]
Calculated MW 43 kDa