ARG58984
anti-SETD7 antibody
anti-SETD7 antibody for ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SETD7 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SETD7 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-366 of Human SETD7 (NP_085151.1). |
| Conjugation | Un-conjugated |
| Alternate Names | SET7/9; KMT7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7; EC 2.1.1.43; Histone-lysine N-methyltransferase SETD7; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; SET9 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse pancreas | ||||||
| Observed Size | 41 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8VHL1 Mouse Histone-lysine N-methyltransferase SETD7 Swiss-port # Q8WTS6 Human Histone-lysine N-methyltransferase SETD7 |
|---|---|
| Gene Symbol | SETD7 |
| Gene Full Name | SET domain containing (lysine methyltransferase) 7 |
| Function | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProt] |
| Cellular Localization | Chromosome, Nucleus. [UniProt] |
| Calculated MW | 41 kDa |
Images (1) Click the Picture to Zoom In
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ARG58984 anti-SETD7 antibody WB image
Western blot: 25 µg of Mouse pancreas lysate stained with ARG58984 anti-SETD7 antibody at 1:1000 dilution.
