ARG42134
anti-SH3GL2 antibody
anti-SH3GL2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Goat Polyclonal antibody recognizes SH3GL2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Pig |
| Tested Application | IHC-P, WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SH3GL2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the internal region of Human SH3GL2. (C-SLEFPTGDSTQPN) (NP_003017.1) |
| Conjugation | Un-conjugated |
| Alternate Names | SH3P4; SH3 domain-containing GRB2-like protein 2; EEN-B1; Endophilin-A1; CNSA2; Endophilin-1; SH3D2A; SH3 domain protein 2A |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | Human frontal cortex | ||||||
| Observed Size | ~ 40 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SH3GL2 |
| Gene Full Name | SH3-domain GRB2-like 2 |
| Function | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. [UniProt] |
| Cellular Localization | Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Note=Concentrated in presynaptic nerve terminals in neurons. [UniProt] |
| Calculated MW | 40 kDa |
