ARG44930
anti-SH3RF1 antibody
anti-SH3RF1 antibody for Immunoprecipitation,Western blot and Human,Mouse
Overview
| Product Description | Mouse Monoclonal antibody recognizes SH3RF1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Target Name | SH3RF1 |
| Antigen Species | Human |
| Epitope | GNSSATKPDK DSKKEKKGLL KLLSGASTKR KPRVSPPASP TLEVELGSAE LPLQGAVGPE LPPGGGHGRA GSCPVDGDGP VTTAVAGAAL AQDAFHRKAS SLDSAVPIAP PPRQACSSLG PVLNESRPVV CERHRVVVSY PPQSEAELEL KEGDIVFVHK KREDGWFKGT LQRNGKTGLF |
| Conjugation | Un-conjugated |
| Alternate Names | SH3RF1; SH3 Domain Containing Ring Finger 1; RNF142; POSH; KIAA1494; SH3MD2; SH3 Domain-Containing RING Finger Protein 1; RING-Type E3 Ubiquitin Transferase SH3RF1; E3 Ubiquitin-Protein Ligase SH3RF1; SH3 Multiple Domains Protein 2; SH3 Multiple Domains 2; Plenty Of SH3 Domains; Plenty Of SH3s; Putative E3 Ubiquitin-Protein Ligase SH3RF1; Ring Finger Protein 142; RING Finger Protein 142; Protein POSH; EC 2.3.2.27; EC 6.3.2; POSH1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | SH3RF1 |
|---|---|
| Gene Full Name | SH3 Domain Containing Ring Finger 1 |
| Background | This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008] |
| Function | Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4+ and CD8+ T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4+ T-cells and the activation of MAPK8/JNK1 in CD8+ T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly |
| Cellular Localization | Cell projection, Cytoplasm, Golgi apparatus |
| Calculated MW | 93 kDa |
| PTM | Phosphoprotein, Ubl conjugation |
