ARG24124
anti-SHANK1 antibody [N22/21]
anti-SHANK1 antibody [N22/21] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [N22/21] recognizes SHANK1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Specificity | 190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | N22/21 |
| Isotype | IgG1 |
| Target Name | SHANK1 |
| Antigen Species | Rat |
| Immunogen | Fusion protein amino acids 469-691 of Rat Shank1 |
| Conjugation | Un-conjugated |
| Protein Full Name | SH3 and multiple ankyrin repeat domains protein 1 |
| Alternate Names | SHANK1; SH3 And Multiple Ankyrin Repeat Domains 1; SSTRIP; Somatostatin Receptor-Interacting Protein; SPANK-1; SH3 And Multiple Ankyrin Repeat Domains Protein 1; SSTR-Interacting Protein; Synamon; SYNAMON; Shank1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SHANK1 |
| Gene Full Name | SH3 And Multiple Ankyrin Repeat Domains 1 |
| Background | This gene encodes a member of the SHANK (SH3 domain and ankyrin repeat containing) family of proteins. Members of this family act as scaffold proteins that are required for the development and function of neuronal synapses. Deletions in this gene may be associated with autism spectrum disorder in males. |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Cellular Localization | Cytoplasm, Synapse |
| Calculated MW | 224 kDa |
| PTM | Methylation, Phosphoprotein |
