ARG24122
anti-SHANK2 (pan) antibody [N23b/49]
anti-SHANK2 (pan) antibody [N23b/49] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [N23b/49] recognizes SHANK2 (pan) |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, IP, WB |
| Specificity | ~160kDa. Recognizes Shank1, 2 and 3. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | N23b/49 |
| Isotype | IgG1 |
| Target Name | SHANK2 (pan) |
| Antigen Species | Rat |
| Immunogen | Fusion protein amino acids of rat Shank2 |
| Conjugation | Un-conjugated |
| Alternate Names | SHANK2; SH3 And Multiple Ankyrin Repeat Domains 2; CTTNBP1; SPANK-3; CORTBP1; SHANK; SH3 And Multiple Ankyrin Repeat Domains Protein 2; Cortactin-Binding Protein 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SHANK2 |
| Gene Full Name | SH3 And Multiple Ankyrin Repeat Domains 2 |
| Background | This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Cellular Localization | Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse |
| PTM | Glycoprotein, Phosphoprotein |
