ARG57588
anti-SIK2 antibody
anti-SIK2 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SIK2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SIK2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human SIK2. |
| Conjugation | Un-conjugated |
| Alternate Names | SNF1LK2; Serine/threonine-protein kinase SIK2; QIK; LOH11CR1I; Qin-induced kinase; Salt-inducible kinase 2; SIK-2; EC 2.7.11.1; Serine/threonine-protein kinase SNF1-like kinase 2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HepG2 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8CFH6 Mouse Serine/threonine-protein kinase SIK2 Swiss-port # Q9H0K1 Human Serine/threonine-protein kinase SIK2 |
|---|---|
| Gene Symbol | SIK2 |
| Gene Full Name | salt-inducible kinase 2 |
| Function | Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. [UniProt] |
| Calculated MW | 104 kDa |
| PTM | Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6. [UniProt] |
