ARG40314
anti-SIK3 antibody
anti-SIK3 antibody for ICC/IF,Western blot and Human,Rat
Overview
| Product Description | Chicken Polyclonal antibody recognizes SIK3 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Predict Reactivity | Ms |
| Tested Application | ICC/IF, WB |
| Specificity | At least three isoforms of SIK3 are known to exist. This antibody will detect two isoforms. This SIK3 antibody is predicted to not cross-react with SIK1 and SIK2. |
| Host | Chicken |
| Clonality | Polyclonal |
| Isotype | IgY |
| Target Name | SIK3 |
| Antigen Species | Human |
| Immunogen | An 18 amino acid synthetic peptide within aa. 1190 - 1240 of Human SIK3. |
| Conjugation | Un-conjugated |
| Alternate Names | SIK-3; L19; QSK; Serine/threonine-protein kinase SIK3; Salt-inducible kinase 3; Serine/threonine-protein kinase QSK; EC 2.7.11.1 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Rat brain |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y2K2 Human Serine/threonine-protein kinase SIK3 |
|---|---|
| Gene Symbol | SIK3 |
| Gene Full Name | SIK family kinase 3 |
| Function | Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling. [UniProt] |
| Cellular Localization | Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ. [UniProt] |
| Calculated MW | Isoform 1: 145 kDa Isoform 2: 70 kDa |
| PTM | Phosphorylated at Thr-163 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. [UniProt] |
