ARG40164
anti-SIN3A antibody
anti-SIN3A antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SIN3A |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SIN3A |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the C-terminus of Human SIN3A. |
| Conjugation | Un-conjugated |
| Alternate Names | Transcriptional corepressor Sin3a; Paired amphipathic helix protein Sin3a; Histone deacetylase complex subunit Sin3a |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Positive Control | K562 | ||||||||||
| Observed Size | 150 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q60520 Mouse Paired amphipathic helix protein Sin3a Swiss-port # Q96ST3 Human Paired amphipathic helix protein Sin3a |
|---|---|
| Gene Symbol | SIN3A |
| Gene Full Name | SIN3 transcription regulator family member A |
| Background | The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008] |
| Function | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. [UniProt] |
| Cellular Localization | Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L. [UniProt] |
| Calculated MW | 145 kDa |
| PTM | SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2. [UniProt] |
