ARG42034

anti-SLC7A11 / xCT antibody

anti-SLC7A11 / xCT antibody for Western blot and Mouse,Rat

Ferroptosis/Oxytosis Study antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes SLC7A11 / xCT
Tested Reactivity Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name SLC7A11 / xCT
Antigen Species Human
Immunogen Synthetic peptide within aa. 150-250 of Human SLC7A11 (NP_055146.1).
Conjugation Un-conjugated
Alternate Names xCT; CCBR1; Cystine/glutamate transporter; Solute carrier family 7 member 11; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Mouse liver
Observed Size ~ 37 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 26570 Mouse SLC7A11

Swiss-port # Q9WTR6 Mouse Cystine/glutamate transporter

Gene Symbol SLC7A11
Gene Full Name solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Background This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Function Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. [UniProt]
Cellular Localization Membrane; Multi-pass membrane protein. [UniProt]
Highlight Related products:
SLC7A11 antibodies; SLC7A11 Duos / Panels; Anti-Rabbit IgG secondary antibodies;
Related news:
Ferroptosis/Oxytosis Antibody Panel is launched
Therapeutic strategies against PDAC
Research Area Ferroptosis/Oxytosis Study antibody
Calculated MW 55 kDa