ARG44085
anti-SLC8A1 antibody
anti-SLC8A1 antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal recognizes SLC8A1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SLC8A1 |
| Antigen Species | Human |
| Immunogen | Human SLC8A1 recombinant protein (Position: E301-Q686). |
| Conjugation | Un-conjugated |
| Alternate Names | SLC8A1; Solute Carrier Family 8 Member A1; NCX1; Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1; Solute Carrier Family 8 Member 1; Na(+)/Ca(2+)-Exchange Protein 1; Sodium/Calcium Exchanger 1; Na+/Ca++ Exchanger; Na+/Ca2+ Exchanger; CNC |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SLC8A1 |
| Gene Full Name | Solute Carrier Family 8 Member A1 |
| Background | In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation. |
| Function | Mediates the exchange of one Ca2+ ion against three to four Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. |
| Cellular Localization | Cell membrane, Membrane |
| Calculated MW | 109 kDa |
| PTM | Glycoprotein, Phosphoprotein |
