ARG43402
anti-SLCO1B1 / OATP1B1 antibody
anti-SLCO1B1 / OATP1B1 antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SLCO1B1 / OATP1B1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SLCO1B1 / OATP1B1 |
| Antigen Species | Human |
| Immunogen | A 14-amino acid synthetic peptide within aa. 641-691 of Human SLCO1B1 / OATP1B1. |
| Conjugation | Un-conjugated |
| Alternate Names | OATP-C; LST1; OATPC; SLC21A6; HBLRR; LST-1; Sodium-independent organic anion-transporting polypeptide 2; OATP-2; OATP2; Solute carrier organic anion transporter family member 1B1; Solute carrier family 21 member 6; Liver-specific organic anion transporter 1; OATP1B1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Human liver | ||||||
| Observed Size | ~ 80 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9Y6L6 Human Solute carrier organic anion transporter family member 1B1 |
|---|---|
| Gene Symbol | SLCO1B1 |
| Gene Full Name | solute carrier organic anion transporter family, member 1B1 |
| Background | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] |
| Function | Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. [UniProt] |
| Cellular Localization | Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes. [UniProt] |
| Calculated MW | 76 kDa |
