ARG43401
anti-SLCO1B3 / OATP1B3 antibody
anti-SLCO1B3 / OATP1B3 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SLCO1B3 / OATP1B3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SLCO1B3 / OATP1B3 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide between aa. 639-668 of Human SLCO1B3 / OATP1B3. |
| Conjugation | Un-conjugated |
| Alternate Names | Organic anion-transporting polypeptide 8; LST3; Liver-specific organic anion transporter 2; OATP1B3; LST-3TM13; HBLRR; LST-2; SLC21A8; Solute carrier family 21 member 8; Organic anion transporter 8; OATP-8; Solute carrier organic anion transporter family member 1B3; OATP8 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HeLa and NCI-H460 | ||||
| Observed Size | 85, 110-120 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9NPD5 Human Solute carrier organic anion transporter family member 1B3 |
|---|---|
| Gene Symbol | SLCO1B3 |
| Gene Full Name | solute carrier organic anion transporter family, member 1B3 |
| Background | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017] |
| Function | Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. [UniProt] |
| Cellular Localization | Basolateral cell membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 77 kDa |
| PTM | N-glycosylated. [UniProt] |
