ARG55109

anti-SLPI antibody

anti-SLPI antibody for ELISA,Immunohistochemistry,Western blot and Human,Mouse

Cell Biology and Cellular Response antibody; Immune System antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes SLPI
Tested Reactivity Hu, Ms
Tested Application ELISA, IHC, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name SLPI
Antigen Species Human
Immunogen Synthetic peptide (17 aa) within aa. 60-110 of Human SLPI.
Conjugation Un-conjugated
Alternate Names HUSI-1; Antileukoproteinase; WAP4; Protease inhibitor WAP4; ALK1; WAP four-disulfide core domain protein 4; BLPI; MPI; HUSI; Secretory leukocyte protease inhibitor; Seminal proteinase inhibitor; Mucus proteinase inhibitor; HUSI-I; WFDC4; ALP

Application Instructions

Application Suggestion
Tested Application Dilution
ELISAAssay-dependent
IHC10 μg/ml
WB1 - 2 μg/ml
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Daudi Cell Lysate

Properties

Form Liquid
Purification Affinity purification with immunogen.
Buffer PBS and 0.02% Sodium azide
Preservative 0.02% Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 20568 Mouse SLPI

GeneID: 6590 Human SLPI

Swiss-port # P03973 Human Antileukoproteinase

Swiss-port # P97430 Mouse Antileukoproteinase

Gene Symbol SLPI
Gene Full Name secretory leukocyte peptidase inhibitor
Background SLPI Antibody: Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-κB activation by inhibiting IκB degradation in the cytoplasm and competing for NF-κB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.
Function Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues. [UniProt]
Research Area Cell Biology and Cellular Response antibody; Immune System antibody
Calculated MW 14 kDa