ARG63416
anti-SM22 alpha / Transgelin antibody
anti-SM22 alpha / Transgelin antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cell Biology and Cellular Response antibody; Controls and Markers antibody; Signaling Transduction antibody; Smooth Muscle Marker antibody
2
Publication1
Overview
Product Description | Goat Polyclonal antibody recognizes SM22 Alpha / Transgelin |
---|---|
Tested Reactivity | Hu |
Predict Reactivity | Ms, Rat, Cow, Dog |
Tested Application | IHC-P, WB |
Specificity | NP_003177.2 and NP_001001522.1 represent identical protein. The transgelin protein is found in fibroblasts and smooth muscle and is known as a transformation or shape change protein that is involved with actin cross-linking. Transgelin is one of the earliest markers of differentiated smooth muscle cells and recent evidence suggests that transgelin acts as a tumour suppressor. |
Host | Goat |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | SM22 alpha / Transgelin |
Antigen Species | Human |
Immunogen | C-MTGYGRPRQIIS |
Conjugation | Un-conjugated |
Alternate Names | SM22-alpha; 22 kDa actin-binding protein; Smooth muscle protein 22-alpha; Protein WS3-10; Transgelin; WS3-10; TAGLN1; SMCC; SM22 |
Application Instructions
Application Suggestion |
|
||||||
---|---|---|---|---|---|---|---|
Application Note | WB: Recommend incubate at RT for 1h. IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
---|---|
Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
Preservative | 0.02% Sodium azide |
Stabilizer | 0.5% BSA |
Concentration | 0.5 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
---|---|
Background | The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
Highlight | Related Antibody Duos and Panels: ARG30293 Smooth Muscle Marker Related products: SM22 alpha antibodies; SM22 alpha Duos / Panels; Anti-Goat IgG secondary antibodies; Related news: Besides tumor suppression, what’s p53 busy for during embryogenesis? |
Research Area | Cell Biology and Cellular Response antibody; Controls and Markers antibody; Signaling Transduction antibody; Smooth Muscle Marker antibody |
Calculated MW | 23 kDa |
Customer's Feedback