ARG67147
anti-SNAIL antibody
anti-SNAIL antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SNAIL |
|---|---|
| Tested Reactivity | Hu, Ms |
| Predict Reactivity | Mk |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SNAIL |
| Antigen Species | Human |
| Immunogen | Synthesized peptide corresponding to a.a. 215-264 of Human SNAIL. |
| Conjugation | Un-conjugated |
| Alternate Names | SNAI1; Snail Family Transcriptional Repressor 1; SNAH; SLUGH2; SNAIL1; SNAIL; SNA; Snail Family Zinc Finger 1; Zinc Finger Protein SNAI1; Protein Snail Homolog 1; Protein Sna; Snail 1 (Drosophila Homolog), Zinc Finger Protein; Snail Homolog 1 (Drosophila); Snail 1 Zinc Finger Protein; Snail 1 Homolog; Snail Homolog 1; DJ710H13.1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% glycerol and 0.5% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SNAI1 |
| Gene Full Name | Snail Family Transcriptional Repressor 1 |
| Background | The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008] |
| Function | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. [UniProt] |
| Cellular Localization | Cytoplasm, Nucleus. [UniProt] |
| Highlight | Related products: SNAIL antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Understanding Your Cells: Choose the right markers SM5-1, a promising immunotherapy for Hepatocellular Carcinoma (HCC) |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody |
| Calculated MW | 29 kDa |
| PTM | ADP-ribosylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation. [UniProt] |
