ARG41056
anti-SORL1 / SorLA antibody
anti-SORL1 / SorLA antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SORL1 / SorLA |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SORL1 / SorLA |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 2065-2214 of Human SORL1 (NP_003096.1). |
| Conjugation | Un-conjugated |
| Alternate Names | SorLA-1; SorLA; LRP9; LR11; C11orf32; SORLA; gp250; Sorting protein-related receptor containing LDLR class A repeats; LDLR relative with 11 ligand-binding repeats; Sortilin-related receptor; Low-density lipoprotein receptor relative with 11 ligand-binding repeats |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | HepG2 | ||||
| Observed Size | 290 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SORL1 |
| Gene Full Name | sortilin-related receptor, L(DLR class) A repeats containing |
| Background | This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010] |
| Function | Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Golgi apparatus. Endosome. Secreted. [UniProt] |
| Calculated MW | 248 kDa |
| PTM | The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases. [UniProt] |
