ARG54002
anti-SOX2 antibody
anti-SOX2 antibody for Flow cytometry,Western blot and Human,Mouse
Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody
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Overview
Product Description | Mouse Monoclonal antibody recognizes SOX2 |
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Tested Reactivity | Hu, Ms |
Tested Application | FACS, WB |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Target Name | SOX2 |
Antigen Species | Mouse |
Immunogen | Purified recombinant mouse Sox2 protein fragments expressed in E.coli |
Conjugation | Un-conjugated |
Alternate Names | Transcription factor SOX-2; MCOPS3; ANOP3 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
Observed Size | 35 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified |
Buffer | 0.1M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% Sodium azide and 50% Glycerol |
Preservative | 0.2% Sodium azide |
Stabilizer | 50% Glycerol |
Concentration | Lot dependent |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | Sox2 |
Gene Full Name | SRY (sex determining region Y)-box 2 |
Function | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). [UniProt] |
Cellular Localization | Nucleus |
Research Area | Developmental Biology antibody; Gene Regulation antibody; Neuroscience antibody |
Calculated MW | 34 kDa |
PTM | Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. |
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