ARG66840
anti-SRCIN1 / p140Cap antibody
anti-SRCIN1 / p140Cap antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SRCIN1 / p140Cap |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SRCIN1 / p140Cap |
| Antigen Species | Human |
| Immunogen | Synthetic peptide between aa. 811-860 of Human SRCIN1 / p140Cap. |
| Conjugation | Un-conjugated |
| Alternate Names | p130Cas-associated protein; SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; p140Cap; SNIP; P140 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | 293T, HeLa and HepG2 | ||||
| Observed Size | 130 ~ 140 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol and 0.5% BSA |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SRCIN1 |
| Gene Full Name | SRC kinase signaling inhibitor 1 |
| Function | Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. [UniProt] |
| Cellular Localization | Cytoplasm, cytoskeleton. Cell projection, axon, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions. [UniProt] |
| Calculated MW | 127 kDa |
| PTM | Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. [UniProt] |
