ARG57448
anti-SSB antibody
anti-SSB antibody for Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes SSB |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Specificity | This antibody detects endogenous levels of SSB and does not cross-react with related proteins. |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | SSB |
| Antigen Species | Human |
| Immunogen | Purified recombinant Human SSB protein fragments expressed in E. coli. |
| Conjugation | Un-conjugated |
| Alternate Names | LARP3; Sjoegren syndrome type B antigen; La; La ribonucleoprotein; Lupus La protein; La autoantigen; La/SSB; SS-B |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 0.03% Proclin300 and 50% Glycerol. |
| Preservative | 0.03% Proclin300 |
| Stabilizer | 50% Glycerol |
| Concentration | 2.6 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SSB |
| Gene Full Name | Sjogren syndrome antigen B (autoantigen La) |
| Background | The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014] |
| Function | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. [UniProt] |
| Cellular Localization | Nucleus. |
| Calculated MW | 47 kDa |
| PTM | Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked. |
