ARG57614
anti-STAM1 antibody
anti-STAM1 antibody for Western blot and Human,Mouse,Rat
1
Overview
| Product Description | Rabbit Polyclonal antibody recognizes STAM1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | STAM1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human STAM1. |
| Conjugation | Un-conjugated |
| Protein Full Name | Signal transducing adapter molecule 1 |
| Alternate Names | STAM; Signal Transducing Adaptor Molecule; STAM1; Signal Transducing Adaptor Molecule (SH3 Domain And ITAM Motif); Signal Transducing Adapter Molecule 1; STAM-1; HSE1 Homolog (S. Cerevisiae); HSE1 Homolog |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Jurkat | ||||
| Observed Size | 70 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P70297 Mouse Signal transducing adapter molecule 1 Swiss-port # Q92783 Human Signal transducing adapter molecule 1 |
|---|---|
| Gene Symbol | STAM |
| Gene Full Name | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 |
| Background | This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011] |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. [UniProt] |
| Cellular Localization | Cytoplasm, Endosome, Membrane |
| Calculated MW | 59 kDa |
| PTM | sopeptide bond, Phosphoprotein, Ubl conjugation |
Customer's Feedback
Good
Review for anti-STAM1 antibody
Application：WB
Sample：293T and 3T3
Sample Loading Amount：20 µg
Primary Antibody Dilution Factor：1:1000
Primary Antibody Incubation Time：overnight
Primary Antibody Incubation Temperature：4 ºC
