ARG54106
anti-SWAP70 antibody
anti-SWAP70 antibody for Western blot,Immunoprecipitation and Human,Mouse,Rat,Monkey
Immune System antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes SWAP70 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Mk |
| Tested Application | IP, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Target Name | SWAP70 |
| Antigen Species | Human |
| Immunogen | Purified recombinant human SWAP70 protein fragments expressed in E.coli. |
| Conjugation | Un-conjugated |
| Alternate Names | SWAP-70; Switch-associated protein 70; HSPC321 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 70 kDa |
Properties
| Form | Liquid |
|---|---|
| Buffer | Ascites |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SWAP70 |
| Gene Full Name | SWAP switching B-cell complex 70kDa subunit |
| Background | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which,_x000D_ independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane_x000D_ ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated_x000D_ phosphatidylinositol (3,4)-bisphosphate production and cell protrusion |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). [UniProt] |
| Cellular Localization | Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. |
| Research Area | Immune System antibody; Signaling Transduction antibody |
| Calculated MW | 69 kDa |
| PTM | Tyrosine-phosphorylated. |
