ARG44609
anti-Siglec 10 antibody [5G6] (APC)
anti-Siglec 10 antibody [5G6] (APC) for Flow cytometry and Human
Overview
| Product Description | APC-conjugated Mouse Monoclonal antibody recognizes Siglec 10 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 5G6 |
| Isotype | IgG1 |
| Target Name | Siglec 10 |
| Antigen Species | Human |
| Immunogen | SIGLEC10 extracellular domain fused with human IgG1 Fc fragment |
| Conjugation | APC |
| Alternate Names | SIGLEC10; Sialic Acid Binding Ig Like Lectin 10; SLG2; SIGLEC-10; PRO940; Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7; Sialic Acid-Binding Ig-Like Lectin 10; Siglec-Like Protein 2; Siglec-Like Gene 2; MGC126774; Sialic Acid Binding Ig-Like Lectin 10; Siglec-10 |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified antibody is conjugated with activated allophycocyanin (APC), and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q96LC7 Human Sialic acid-binding Ig-like lectin 10 |
|---|---|
| Gene Symbol | SIGLEC10 |
| Gene Full Name | sialic acid binding Ig-like lectin 10 |
| Background | SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] |
| Function | During initiation of adaptive immune responses by CD8-alpha+ dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification. [UniProt] |
| Cellular Localization | Cell membrane, Membrane, Secreted. [UniProt] |
| Calculated MW | 77 kDa |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein. [UniProt] |
