ARG59877
anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D]
anti-Slow Skeletal Myosin Heavy chain antibody [NOQ7.5.4D] for ELISA,Electron microscopy,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Radioimmunoassay,Western blot and Human,Mouse,Rat,Rabbit
Overview
| Product Description | Mouse Monoclonal antibody [NOQ7.5.4D] recognizes Slow Skeletal Myosin Heavy chain |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Rb |
| Tested Application | ELISA, EM, ICC/IF, IHC-P, RIA, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | NOQ7.5.4D |
| Isotype | IgG1 |
| Target Name | Slow Skeletal Myosin Heavy chain |
| Antigen Species | Human |
| Immunogen | Human skeletal muscle myosin purified from myofibrils. |
| Conjugation | Un-conjugated |
| Alternate Names | SPMD; MyHC-slow; SPMM; Myosin heavy chain 7; CMD1S; Myosin heavy chain, cardiac muscle beta isoform; MyHC-beta; MPD1; MYHCB; CMH1; Myosin heavy chain slow isoform; Myosin-7 |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: By heat mediation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Unpurified. |
| Buffer | Ascites fluid, 1.2% Sodium acetate, 0.01% Sodium azide and 2% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 2% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MYH7 |
| Gene Full Name | myosin, heavy chain 7, cardiac muscle, beta |
| Background | Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008] |
| Function | Muscle contraction. [UniProt] |
| Cellular Localization | Cytoplasm, myofibril. Thick filaments of the myofibrils. [UniProt] |
| Calculated MW | 223 kDa |
