ARG65886
anti-Sp7 / Osterix antibody
anti-Sp7 / Osterix antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Rabbit
Publication2
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Sp7 / Osterix |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Rb |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Sp7 / Osterix |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide around aa. 340-400 of Human Sp7 / Osterix. |
| Conjugation | Un-conjugated |
| Alternate Names | Transcription factor Sp7; OI11; osterix; OSX; OI12; Zinc finger protein osterix |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | Aqueous buffered solution, 0.09% Sodium azide, 50% Glycerol and 1% BSA. |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol and 1% BSA |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SP7 |
| Gene Full Name | Sp7 transcription factor |
| Background | This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010] |
| Function | Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). [UniProt] |
| Cellular Localization | Nucleus |
| Calculated MW | 45 kDa |
| PTM | Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours. |
Specific References
Liraglutide in Combination with Insulin Has a Superior Therapeutic Effect to Either Alone on Fracture Healing in Diabetic Rats
WB / Rats
Silicosis decreases bone mineral density in rats.
IHC-P / Rat
